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Bioinformatics Scientist

Spectraforce Technologies
United States, Massachusetts, Cambridge
Jul 03, 2025
Bioinformatics Scientist

23 months

Cambridge, MA 02141


Qualifications:

Required Qualifications:

* Ph.D. in Computational Biology or a related field.

* A proven track record of over 3 years in multi-omics analysis.

* Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).

* Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.

* Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

* A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.

* Excellent written and verbal communication skills.

Preferred Qualifications:

* Experience in processing and analyzing real-world data.

* Familiarity with spatial transcriptomics analysis.

* Knowledge of statistical and population genetics principles.

Responsibilities:

Location: Cambridge, MA

Department: Data and Genome Sciences

Group: Precision Genetics

The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team. We are looking for a data scientist with extensive experience in multi-modal and multi-scale data analyses to contribute to our innovative research efforts.

Key Responsibilities:

* Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).

* RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).

* Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).

* Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.

* Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.

Key Skills:

* Required expertise with multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq)

* Transcriptomics analysis.

* Proficiency in R and Bash.

* High-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

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