Senior Scientist, Delivery Sciences (Immunology)

Join our innovative RNAi Platform team, committed to pioneering delivery breakthroughs leading to multiple RNAi-based therapeutics. We are seeking a highly motivated and accomplished Senior Scientist with a strong academic foundation in immunology and proven industry experience in drug discovery for immune-related diseases. This is a lab-based role in which you will lead critical efforts in utilizing immunology techniques to unlock delivery to immune cells to advance of next-generation immunomodulatory therapies targeting unmet clinical needs.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Develop and lead advanced in vitro and ex vivo immune assay platforms.
• Develop and optimize in vivo immune-related murine disease models.
• Integrate and interpret multi-parametric flow cytometry data.
• Collaborate with platform teams, early development groups, and external CROs to support cross-functional research objectives.
• Present scientific findings at internal governance meetings, contribute to external publications, and support IND-enabling research.

Qualifications

• Ph.D. in Immunology, Cell Biology, or a related discipline, with a focus on immune-related disease mechanisms.
• A total of 3-6 years of relevant experience in translational immunology and cell biology, including academic postdoctoral training and preferably 2+ years of industry experience.
• Strong expertise in adaptive immunology, murine disease models, and immune-mediated tissue damage.
• Strong publication record in peer-reviewed journals in cell biology, immunology, or translational research.
• Proven expertise in:
  • Primary immune cell culture
  • Flow cytometry (high-parameter analysis, cell sorting)
  • Biomarker assays (ELISA, MSD, cytokine profiling)
  • qPCR, IHC, scRNA-seq, and bioinformatics pipelines (R, IPA)
• Direct experience with oligonucleotide-based therapeutics is a plus.
• Demonstrated ability to independently design, execute, and interpret complex biological experiment.
• Excellent communication, collaboration, and interpersonal skills, with the ability to present data clearly and effectively in both written and oral formats, and to work productively across multidisciplinary teams.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.