Senior Scientist, Delivery Sciences (Kidney)

We are seeking a Senior Scientist to join our Delivery Sciences team group to help with our kidney delivery efforts. The candidate must be independent, goal oriented, technically competent, and able to work efficiently across multiple projects as well as cross-functionally. We are searching for enthusiastic, innovative, and highly motivated individuals. The candidate must have a scientific background in kidney biology and physiology with demonstrated experience in designing and characterizing preclinical models of human disease as well as kidney in vitro models. This is a laboratory-based position located at Alnylam's Cambridge office.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Develop and characterize renal complex in-vitro systems for evaluating target engagement (healthy and diseased).
• Develop in vivo disease models to assess pharmacological efficacy and validate therapeutic hypotheses.
• Execute standard molecular biology techniques (RT-qPCR, ELISA, Western blots, etc.).
• Work cross-functionally with teams across the organization to contribute to the strategic direction of kidney programs through carful experimental design and execution.
• Proper electronic notebook record keeping with high attention to detail.
• Clear communication of experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• PhD in Cell Biology, Molecular Biology, or related field with 3-5 years of relevant kidney experience in a biopharma or academic setting.
• Deep understanding of kidney biology, physiology and pathology.
• Extensive experience with advanced cell culture systems including stem cell culture, 3D cultures, or organoids.
• Strong background in molecular biology techniques, imaging, and data analysis are required.
• Experience with oligonucleotide-based therapeutics will be preferred.
• Detail oriented, self-motivated, and comfortable working with cross-functional teams.
• Ability to work on multiple projects simultaneously and deliver conclusive results.
• Highly adaptable and responsive to new priorities in a fast-paced environment.
• Effective written and oral communication skills.
• Experience with ELN recording keeping.
  
  

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.