Associate Director, Research (Targeted Delivery)

The Research Department at Alnylam is seeking an Associate Director to lead a team responsible for advancing RNAi therapeutics into the future, by opening up targeted delivery to all tissues. The individual will need excellent collaboration and communication skills, connecting team members from multiple areas. The successful candidate will have excellent knowledge of biochemistry/biological sciences with experience in receptor identification/characterization (unbiased screens) and affinity ligand discovery (antibody, peptide, etc.), This role requires in-depth expertise in tools and techniques to identify receptors and characterize ligand-receptor interactions. Expertise in ligand selection approaches (e.g. phage display, yeast display) is essential. Experience in the field of antibody drug conjugates is a plus.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Lead an interdisciplinary team to execute goals of targeted delivery into new cell types and tissues.
• Manage external collaborations relating to receptor identification and ligand development for targeted delivery.
• Establish tools, techniques and assays to identify new receptors, develop new binding ligands, and characterize ligand-receptor interactions, which may include recombinant protein production, binding assays, and cell-based assays to assess receptor engagement and functional siRNA delivery.
• Transparently communicate results with key stakeholders throughout the organization.

Qualifications

• PhD in Biochemistry, Molecular Biology, Cell Biology, or related field.
• 8+ years of experience in biopharma setting.
• Expertise in ligand selection approaches and receptor biology.
• Strong background and in-depth understanding of protein chemistry, receptor identification, biochemical characterization of ligand-receptor interactions including binding and uptake.
• Experience in the field of antibody drug conjugates and nucleic acid conjugates will be a plus
• Strong track record of working in interdisciplinary, collaborative team-based research environment and leadership of research projects.
• Excellent communication skills (both written and oral) are essential.
  
  

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.